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Detection of human adaptation during the past 2,000 years

Abstract:

Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the Singleton Density Score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past ~2,000-3,000 years. We see strong signals of selection at lactase and the MHC, and in favor of blond hair and blue eyes. For polygen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/science.aag0776

Authors


Gaulton, KJ More by this author
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Grant:
ES025009, 5T32HG000044-19 and MH101825
Howard Hughes Medical Institute More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
354
Issue:
6313
Pages:
760-764
Publication date:
2016-10-05
Acceptance date:
2016-10-03
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:652689
URN:
uri:f329065b-aaf9-429b-a15e-dad0e2e149ae
UUID:
uuid:f329065b-aaf9-429b-a15e-dad0e2e149ae
Local pid:
pubs:652689

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