- Abstract:
-
Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the Singleton Density Score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to data from the UK10K Project, SDS reflects allele frequency changes in the ancestors of modern Britons during the past ~2,000-3,000 years. We see strong signals of selection at lactase and the MHC, and in favor of blond hair and blue eyes. For polygen...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 199.2kb)
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(pdf, 25.0mb)
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(pdf, 429.4kb)
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(pdf, 121.0kb)
-
(pdf, 45.8kb)
-
(pdf, 120.8kb)
-
- Publisher copy:
- 10.1126/science.aag0776
-
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- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 354
- Issue:
- 6313
- Pages:
- 760-764
- Publication date:
- 2016-10-05
- Acceptance date:
- 2016-10-03
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Pubs id:
-
pubs:652689
- URN:
-
uri:f329065b-aaf9-429b-a15e-dad0e2e149ae
- UUID:
-
uuid:f329065b-aaf9-429b-a15e-dad0e2e149ae
- Local pid:
- pubs:652689
- Copyright holder:
- Field et al.
- Copyright date:
- 2016
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: http://dx.doi.org/10.1126/science.aag0776
Journal article
Detection of human adaptation during the past 2,000 years
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Howard Hughes Medical Institute
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