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Thesis

Mechanisms of cone dysfunction in inherited retinal degenerations

Abstract:

This thesis examines the mechanisms of cone dysfunction in two different inherited retinal diseases: Achromatopsia and Retinitis Pigmentosa (RP). The first, minor, component of the thesis explored and characterised the loss of cone function in a novel mouse model of achromatopsia (cpfl10). The second, major, component of the thesis explored the loss of cone function in a mouse model of RP. I hypothesised that the cone function lost in RP could be restored using AAV vectors to over...

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Mark M Hassall More by this author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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