Journal article

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.

Abstract:: Acetamido derivatives of the naturally antibacterial non-β-lactam lactivicin (LTV) have improved activity against their penicillin binding protein targets and reduced hydrolysis by β-lactamases, but penetration into Gram-negative bacteria is still relatively poor. Here we report that modification of the LTV lactone with a catechol-type siderophore increases potency 1,000-fold against Stenotrophomonas maltophilia, a species renowned for its insusceptibility to antimicrobials. The MIC90 of modi...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Calvopiña, K., Umland, K., Rydzik, A., Hinchliffe, P., Brem, J., Spencer, J., Schofield, C., & Avison, M. (2016). Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates. Antimicrobial Agents and Chemotherapy, 60(7), 4170–4175.

MLA Style

Calvopiña, K., et al. “Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas Maltophilia Clinical Isolates.” Antimicrobial Agents and Chemotherapy, vol. 60, no. 7, American Society for Microbiology, 2016, pp. 4170–75.

Chicago Style

Calvopiña, K, K Umland, A Rydzik, P Hinchliffe, J Brem, J Spencer, C Schofield, and M Avison. 2016. “Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas Maltophilia Clinical Isolates.” Antimicrobial Agents and Chemotherapy 60 (7): 4170–75.
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Files:: Antimicrob. Agents Chemother.-2016-Calvopiña-AAC.00371-16[1].pdf

(Preview, Accepted manuscript, pdf, 4.5MB, Terms of use)

Publisher copy:: 10.1128/AAC.00371-16

Authors

+ Calvopiña, K More by this author

Role:

Author

+ Umland, K More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Role:

Author

+ Rydzik, A More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Role:

Author

+ Hinchliffe, P More by this author

Role:

Author

+ Brem, J More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Role:

Author

More authors...

Funding

+ National Institute of Allergy and Infectious Diseases More from this funder

Grant:

01AI100560

+ Medical Research Council More from this funder

Grant:

MR/L007665/1

G1100135

+ Engineering and Physical Sciences Research Council More from this funder

Grant:

EP/M027546/1

Bibliographic Details

Publisher:: American Society for Microbiology
Journal:: Antimicrobial Agents and Chemotherapy More from this journal
Volume:: 60
Issue:: 7
Pages:: 4170-4175
Publication date:: 2016-05-02
Acceptance date:: 2016-04-24
DOI:: 10.1128/AAC.00371-16
ISSN:: 1098-6596 and 0066-4804
Pmid:: 27139464

Item Description

Language:: English
Keywords:: Journal Article
Pubs id:: pubs:619839
UUID:: uuid:f2f93c28-4afd-4737-848f-16b967b57fcf
Local pid:: pubs:619839
Source identifiers:: 619839
Deposit date:: 2016-11-03

Terms of use

Copyright holder:: American Society for Microbiology
Copyright date:: 2016
Notes:: Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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