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Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)

Abstract:

Primary human hepatocytes are considered to be the "gold standard" cellular model for studying hepatic fatty acid and glucose metabolism; however, they come with limitations. Although the HepG2 cell line retains many of the primary hepatocyte metabolic functions they have a malignant origin and low rates of triglyceride secretion. The aim of this study was to investigate whether dimethyl sulfoxide supplementation in the media of HepG2 cells would enhance metabolic functionality leading to the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.14814/phy2.12944

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Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Radcliffe Department of Medicine, University of Oxford More from this funder
Publisher:
American Physiological Society Publisher's website
Journal:
Physiological Reports Journal website
Volume:
4
Issue:
21
Pages:
e12944-e12944
Publication date:
2016-11-05
DOI:
ISSN:
2051-817X
Pubs id:
pubs:656971
URN:
uri:f2edd7f0-1c50-4a7e-92dc-e8f9a8d47fa3
UUID:
uuid:f2edd7f0-1c50-4a7e-92dc-e8f9a8d47fa3
Local pid:
pubs:656971
Paper number:
21
Language:
English
Keywords:

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