Journal article
Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)
- Abstract:
-
Primary human hepatocytes are considered to be the "gold standard" cellular model for studying hepatic fatty acid and glucose metabolism; however, they come with limitations. Although the HepG2 cell line retains many of the primary hepatocyte metabolic functions they have a malignant origin and low rates of triglyceride secretion. The aim of this study was to investigate whether dimethyl sulfoxide supplementation in the media of HepG2 cells would enhance metabolic functionality leading to the...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Radcliffe Department of Medicine, University of Oxford
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Bibliographic Details
- Publisher:
- American Physiological Society Publisher's website
- Journal:
- Physiological Reports Journal website
- Volume:
- 4
- Issue:
- 21
- Pages:
- e12944-e12944
- Publication date:
- 2016-11-01
- Acceptance date:
- 2016-08-01
- DOI:
- ISSN:
-
2051-817X
- Source identifiers:
-
656971
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:656971
- UUID:
-
uuid:f2edd7f0-1c50-4a7e-92dc-e8f9a8d47fa3
- Local pid:
- pubs:656971
- Deposit date:
- 2016-11-04
Terms of use
- Copyright holder:
- Nikolaou et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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