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Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Abstract:

Macrophages are key target cells of Zika virus (ZIKV) infection, implicated as a viral reservoir seeding sanctuary sites such as the central nervous system and testes. This rests on the apparent ability of macrophages to sustain ZIKV replication without experiencing cytopathic effects. ZIKV infection of macrophages triggers an innate immune response involving type I interferons (IFN-I), key antiviral cytokines that play a complex role in ZIKV pathogenesis in animal models. To investigate the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2022.1035532

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Name:
National Institute for Health Research (NIHR)
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
13
Article number:
1035532
Place of publication:
Switzerland
Publication date:
2022-11-11
Acceptance date:
2022-10-21
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Pmid:
36439115
Language:
English
Keywords:
Pubs id:
1311255
Local pid:
pubs:1311255
Deposit date:
2023-01-09

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