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Functional integrity of visual coding following advanced photoreceptor degeneration

Abstract:

Photoreceptor degeneration sufficient to produce severe visual loss often spares the inner retina. This raises hope for vision restoration treatments using optogenetics or electrical stimulation, which generate a replacement light input signal in surviving neurons. The success of these approaches is dependent on the capacity of surviving circuits of the visual system to generate and propagate an appropriate visual code in the face of neuroanatomical remodeling. To determine whether retinally ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cub.2022.12.026

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Name:
Medical Research Council
Grant:
MR/S026266/1
Publisher:
Cell Press
Journal:
Current Biology More from this journal
Volume:
33
Issue:
3
Pages:
474-486.e5
Publication date:
2023-01-10
Acceptance date:
2022-11-22
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Language:
English
Keywords:
Pubs id:
1308646
Local pid:
pubs:1308646
Deposit date:
2022-11-23

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