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Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage

Abstract:

Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional pro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Acepted manuscript

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Publisher copy:
10.1016/j.ajhg.2017.07.007

Authors


Moradi Marjaneh, M More by this author
Al-Ejeh, F More by this author
More by this author
Department:
Wolfson College
Australian National Breast Cancer Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
101
Issue:
2
Pages:
255-266
Publication date:
2017-08-03
Acceptance date:
2017-07-10
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pubs id:
pubs:712414
URN:
uri:f2d100c8-df09-4477-87dd-08e946e89cd7
UUID:
uuid:f2d100c8-df09-4477-87dd-08e946e89cd7
Local pid:
pubs:712414

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