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Impact of dolutegravir-based antiretroviral therapy on piperaquine exposure following dihydroartemisinin-piperaquine intermittent preventive treatment of malaria in pregnant women living with HIV

Abstract:

Dihydroartemisinin-piperaquine, an artemisinin-based combination therapy, has been identified as a promising agent for intermittent preventive treatment of malaria in pregnancy. However, in pregnant women living with HIV (PLWH), efavirenz-based antiretroviral therapy (ART) significantly reduces the plasma exposure of piperaquine. In an open-label, nonrandomized, fixed-sequence, pharmacokinetic study, we compared piperaquine plasma concentrations in 13 pregnant women during a 3-day treatment c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00584-22

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Role:
Author
ORCID:
0000-0002-0757-5259
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Name:
EC | H2020 | ERA-LEARN | European and Developing Countries Clinical Trials Partnership
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
66
Issue:
12
Article number:
e00584-22
Place of publication:
United States
Publication date:
2022-11-14
Acceptance date:
2022-10-23
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
36374096
Language:
English
Keywords:
Pubs id:
1308333
Local pid:
pubs:1308333
Deposit date:
2023-01-10

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