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Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.

Abstract:

The 85-kb breast cancer-associated gene BRCA1 is an established tumor suppressor gene, but its regulation is poorly understood. We demonstrate by gene conformation analysis in both human cell lines and mouse mammary tissue that gene loops are imposed on BRCA1 between the promoter, introns, and terminator region. Significantly, association between the BRCA1 promoter and terminator regions change upon estrogen stimulation and during lactational development. Loop formation is transcription-depen...

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Publisher copy:
10.1073/pnas.0801048105

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
13
Pages:
5160-5165
Publication date:
2008-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f28b01a5-012c-4462-b7d7-431487a74377
Source identifiers:
23417
Local pid:
pubs:23417

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