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KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

Abstract:
We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/23723556.2016.1270391

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Fournier, M
Grant:
PIIF-GA-2009–255266
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Grant:
ANR-13-BSV6–0001–02 COREAC
Publisher:
Taylor and Francis Publisher's website
Journal:
Molecular and Cellular Oncology Journal website
Volume:
4
Issue:
2
Pages:
e1270391
Publication date:
2016-12-01
Acceptance date:
2016-12-01
DOI:
EISSN:
2372-3556
Source identifiers:
687760
Keywords:
Pubs id:
pubs:687760
UUID:
uuid:f246493c-eeda-4087-a529-04adcb83c714
Local pid:
pubs:687760
Deposit date:
2017-04-03

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