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Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis.

Abstract:

Background.: Tuberculous meningitis (TBM) is the most devastating form of tuberculosis, yet very little is known about the pathophysiology. We hypothesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which determines inflammatory eicosanoid expression, influences intracerebral inflammation, and predicts survival from TBM.

Methods.: We characterized the pretreatment clinical and intracerebral inflammatory phenotype and 9-month survival of 764 adults with...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jix050

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Ramakrishnan, L More by this author
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Li Ka Shing Foundation More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
215
Pages:
1020–8
Publication date:
2017-04-17
Acceptance date:
2017-01-20
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:691086
URN:
uri:f232d07f-4d9d-454a-98cb-eec33017f826
UUID:
uuid:f232d07f-4d9d-454a-98cb-eec33017f826
Local pid:
pubs:691086

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