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Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response

Abstract:

Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how diseas...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2017.0479

Authors


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Institution:
University of Oxford
Division:
MPLS
Role:
Author
Publisher:
Royal Society
Journal:
Journal of the Royal Society Interface More from this journal
Volume:
14
Issue:
136
Pages:
0479
Publication date:
2017-11-15
Acceptance date:
2017-10-18
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pubs id:
pubs:745844
UUID:
uuid:f2312fe8-35c4-4a35-be52-203dc1886c0e
Local pid:
pubs:745844
Deposit date:
2017-11-15

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