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Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis.

Abstract:

Two main pieces of neurobiological evidence are adduced to support an early neurodevelopmental component to schizophrenia. Firstly, an abnormal distribution of neurons, especially interstitial white matter neurons (IWMNs). Secondly, decreased expression of reelin, a key developmental signalling molecule. Although influential, neither result is wholly established, and a possible link between them has not been examined. We addressed both issues, in superior temporal cortex, in 12 subjects with ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.mp.4001371

Authors


Eastwood, SL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Molecular psychiatry
Volume:
8
Issue:
9
Pages:
769-831
Publication date:
2003-09-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:f16dd13d-d8ba-4519-817a-148e19f974e3
Source identifiers:
97924
Local pid:
pubs:97924

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