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Thesis

Understanding the role of the TOPBP1 and BLM interaction in promoting genome stability

Abstract:

The ability to sense, respond to and repair DNA damage is essential in normal development and survival of an organism. A number of human congenital syndromes are associated with mutations in pathways involved in the DNA damage response, including Seckel and Bloom syndromes. Such diseases are often characterised by developmental abnormalities and cancer, emphasising the importance of gaining a deeper understanding of the mechanisms underlying these pathways. The protein kinase ATR, mu...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:f16d9101-1317-4e71-a1d6-bf9124249143
Deposit date:
2018-06-25

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