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Journal article

Conventional and genetic evidence on the association between adiposity and CKD

Abstract:

Background The size of any causal contribution of central and general adiposity to CKD risk and the underlying mechanism of mediation are unknown.

Methods Data from 281,228 UK Biobank participants were used to estimate the relevance of waist-to-hip ratio and body mass index (BMI) to CKD prevalence. Conventional approaches used logistic regression. Genetic analyses used Mendelian randomization (MR) and data from 394 waist-to-hip ratio and 773 BMI-as...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-1172-8243
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0002-1179-0023
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0001-7792-9422
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
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Publisher:
American Society of Nephrology Publisher's website
Journal:
Journal of the American Society of Nephrology Journal website
Place of publication:
United States
Publication date:
2020-10-30
Acceptance date:
2020-09-10
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
Pmid:
33127858
Pubs id:
1140348
Local pid:
pubs:1140348

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