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Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis

Abstract:

Tuberculosis is the world's largest cause of death from an infectious agent. Treatment is by an extended period of combination chemotherapy. Drug resistance is an increasing problem in tuberculosis therapy, particularly to the frontline anti-tubercular drug isoniazid (INH). Recombinant arylamine N-acetyltransferase (NAT) of Mycobacterium tuberculosis N-acetylates INH using the cofactor Acetyl Coenzyme A. NAT from M. tuberculosis is a polymorphic enzyme and also ...

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Institution:
University of Oxford
Department:
Medical Sciences Division

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2003
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603838298
URN:
uuid:f13c3191-b098-4a85-84c3-90590b365d30
Local pid:
td:603838298

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