Journal article
The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro.
- Abstract:
-
BACKGROUND: Combretastatin A-4-phosphate (CA-4-P) is a microtubule depolymerising agent currently in clinical trial as a tumour vascular-targeting agent. In vivo, CA-4-P causes rapid shutdown of tumour blood flow (within minutes) and a significant neutrophil infiltration at later times. MATERIALS AND METHODS: Using an in vitro flow-cell assay, we investigated neutrophil-endothelial cell interactions and associated mechanisms, following endothelial cell exposure to CA-4-P. Cellular adhesion m...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Anticancer research
- Volume:
- 23
- Issue:
- 4
- Pages:
- 3199-3206
- Publication date:
- 2003-01-01
- EISSN:
-
1791-7530
- ISSN:
-
0250-7005
- URN:
-
uuid:f128434d-bd74-43d7-841c-21ea1f9dae4d
- Source identifiers:
-
130857
- Local pid:
- pubs:130857
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- Copyright date:
- 2003
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