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Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers

Abstract:
Introduction

Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. This protocol describes a proposed GWAS on genetic contributions to...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/bmjopen-2018-025530

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0001-7759-0211
Adhikari, K More by this author
Ramirez-Aristeguieta, LM More by this author
Chacón-Duque, J-C More by this author
Poletti, G More by this author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
9
Issue:
4
Pages:
e025530
Publication date:
2019-04-20
Acceptance date:
2019-03-05
DOI:
EISSN:
2044-6055
ISSN:
2044-6055
Pubs id:
pubs:993821
URN:
uri:f0f43535-1693-41f0-a0a9-bc78bee903b9
UUID:
uuid:f0f43535-1693-41f0-a0a9-bc78bee903b9
Local pid:
pubs:993821
Language:
English

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