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Journal article

Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders

Abstract:

Desmosome components are frequently mutated in cardiac and cutaneous disorders in animals and humans and enhanced inflammation is a common feature of these diseases. Previous studies showed that inhibitor of Apoptosis Stimulating p53 Protein (iASPP) regulates desmosome integrity at cell–cell junctions and transcription in the nucleus, and its deficiency causes cardiocutaneous disorder in mice, cattle, and humans. As iASPP is a ubiquitously expressed shuttling protein with multiple functions, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41418-017-0039-6

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
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Funding agency for:
Schneider, JE
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Funding agency for:
Schneider, JE
Ludwig Institute for Cancer Research More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Differentiation Journal website
Volume:
25
Pages:
1289–1303
Publication date:
2018-01-19
Acceptance date:
2017-10-30
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
Pubs id:
pubs:744132
URN:
uri:f0d20bc9-ab76-4bd4-89c9-b1fbbe2ff3a3
UUID:
uuid:f0d20bc9-ab76-4bd4-89c9-b1fbbe2ff3a3
Local pid:
pubs:744132

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