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Initial symptom severity of bipolar I disorder and the efficacy of olanzapine: a meta-analysis of individual participant data from five placebo-controlled studies

Abstract:

Background

The efficacy of antipsychotics across the initial severity range in acute mania remains unclear. Therefore, we decided to examine the influence of baseline severity on the efficacy of olanzapine.

Methods

We conducted an individual participant data (IPD) meta-analysis of five double-blind, randomized controlled trials comparing olanzapine versus placebo. 939 patients with acute mania associated with bipolar I disorder were included. The relationship bet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/s2215-0366(17)30331-0

Authors


Samara, MT More by this author
Goldberg, Y More by this author
Levine, SZ More by this author
Furukawa, TA More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Psychiatry Journal website
Volume:
4
Issue:
11
Pages:
859–867
Publication date:
2017-09-05
Acceptance date:
2017-05-22
DOI:
EISSN:
2215-0374
ISSN:
2215-0366
Pubs id:
pubs:730961
URN:
uri:f0ae67e7-f047-4d85-b869-51b53df93225
UUID:
uuid:f0ae67e7-f047-4d85-b869-51b53df93225
Local pid:
pubs:730961

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