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NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone

Abstract:

Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression. At the start of primary ossification, TrkA-positive axons were observed at peri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.08.002

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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Publication date:
2016-08-25
Acceptance date:
2016-07-31
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:641546
URN:
uri:f068dbaa-00c9-410e-92f6-03a32522bbab
UUID:
uuid:f068dbaa-00c9-410e-92f6-03a32522bbab
Local pid:
pubs:641546

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