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Dimensions and interactions of large T-cell surface proteins

Abstract:

The first step of the adaptive immune response involves the interaction of T cells that express T-cell receptors (TCRs) with peptide-loaded major histocompatibility complexes expressed by antigen-presenting cells (APCs). Exactly how this leads to activation of the TCR and to downstream signaling is uncertain, however. Recent findings suggest that one of the key events is the exclusion of the large receptor-type tyrosine phosphatase CD45, from close contacts formed at sites of T-cell/APC inter...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.02215

Authors


Junghans, V More by this author
Santos, AM More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM - Investigative Medicine Division
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
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ORCID:
0000-0003-2994-8017
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
Article: 2215
Publication date:
2018-09-27
Acceptance date:
2018-09-06
DOI:
ISSN:
1664-3224
Pubs id:
pubs:926111
URN:
uri:f0569c9a-25fe-459f-8f82-a3476765565a
UUID:
uuid:f0569c9a-25fe-459f-8f82-a3476765565a
Local pid:
pubs:926111

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