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iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.

Abstract:

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and qu...

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Publisher copy:
10.1093/nar/gks1323

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Deplancke, B More by this author
Maerkl, SJ More by this author
Journal:
Nucleic acids research
Volume:
41
Issue:
4
Pages:
e52
Publication date:
2013-02-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:f03b2c09-a26e-4a2e-81b4-6ec5f701c9e9
Source identifiers:
367905
Local pid:
pubs:367905

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