Nickel-base superalloys are often used in some of the most challenging applications that require exceptional high-temperature resilience, in terms of the combination of strength, toughness, fatigue and creep resistance, etc. We report an application of a discrete dislocation model to explore the changing hardening performance of a single crystal Ni-base superalloy under cyclic loading as a function of different crystal lattice orientations with respect to the direction of the applied load. We...