Journal article
SuperQuat chiral auxiliaries: design, synthesis, and utility
- Abstract:
-
The SuperQuat (4-substituted 5,5-dimethyloxazolidine-2-one) family of chiral auxiliaries was first developed by us in the 1990s to address the shortcomings of the Evans (4-substituted oxazolidin-2-one) family of chiral auxiliaries. The incorporation of geminal dimethyl substitution at C(5) has two effects: (i) it induces a conformational bias on an adjacent, otherwise conformationally labile C(4)-substituent so that it projects towards the N-acyl fragment, thus offering superior diastereofaci...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 445.1KB, Terms of use)
-
- Publisher copy:
- 10.1039/c8ob02819b
Authors
Bibliographic Details
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic and Biomolecular Chemistry More from this journal
- Volume:
- 17
- Issue:
- 6
- Pages:
- 1322-1335
- Publication date:
- 2018-12-19
- Acceptance date:
- 2018-12-18
- DOI:
- EISSN:
-
1477-0539
- ISSN:
-
1477-0520
- Pmid:
-
30633283
Item Description
- Language:
-
English
- Pubs id:
-
pubs:959960
- UUID:
-
uuid:f01c49bc-566b-41fe-89d8-7343ac7ab7f5
- Local pid:
-
pubs:959960
- Source identifiers:
-
959960
- Deposit date:
-
2019-01-18
Terms of use
- Copyright holder:
- Davies et al
- Copyright date:
- 2018
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from the Royal Society of Chemistry at: https://doi.org/10.1039/c8ob02819b
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record