Structural insights into human SNF2/SWI2 chromatin remodeler SMARCAD1 and its role in DNA repair

Thesis

ATP-dependent chromatin remodelers have been proposed to act sequentially, and to a certain extent non-redundantly, in the priming stages of the DNA Damage Response pathways by establishing chromatin in lesion sites ready to act as a scaffold for repair factors or to be displaced in order to allow DNA repair. Among remodeling factors proposed to play a role in DNA repair is SMARCAD1, a poorly characterized, non-canonical member of the SWR1-like family of SNF2/SWI2 superfamily of ATPases, w...

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Authors: Biasutto, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Protein Structure; Ubiquitin; SMARCAD1; nuclear magnetic resonance; SUMO Interacting Motif; Chromatin Remodelling; SUMO; CUE Domain
• Subjects: NMR Spectroscopy; Biochemistry