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Divergent Memory B Cell Responses in a Mixed Infant Pneumococcal Conjugate Vaccine Schedule

Abstract:

BACKGROUND: Vaccine-induced immunity against pneumococcal infection relies on the generation of high concentrations of antibody and B-cell memory. Both the 10- and the 13-valent pneumococcal conjugate vaccines (PCV-10 and PCV-13) effectively reduce disease caused by vaccine serotypes. It is unknown whether the generation of B-cell memory requires several doses of the same vaccine or whether different PCVs are interchangeable. METHODS: Children in the UK (n=178) who had previously received PCV...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/INF.0000000000001497

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Department:
Oxford, MSD, Paediatrics
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Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
More by this author
Department:
Oxford, MSD, Paediatrics
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National Institute for Health Research More from this funder
Oxford Biomedical Research Centre More from this funder
GSK Biologicals More from this funder
Publisher:
Wolters Kluwer Health, Inc. Publisher's website
Journal:
Pediatric Infectious Disease Journal Journal website
Publication date:
2016-12-23
DOI:
ISSN:
1532-0987
Pubs id:
pubs:667746
URN:
uri:ef8b8fea-d9e2-4010-b2d9-2112eced9122
UUID:
uuid:ef8b8fea-d9e2-4010-b2d9-2112eced9122
Local pid:
pubs:667746
Language:
English
Keywords:

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