Thesis
Characterising novel, humanised and physiological mouse models of FUS-ALS
- Abstract:
-
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition, with mutations in the Fused in Sarcoma (FUS) gene accounting for particularly severe, early onset forms of the disease. Despite extensive research into ALS, there is still no cure, and almost nothing in the way of efficacious treatments. This may be in part due to a lack of physiologically relevant models. Mouse models of ALS, and other neurodegenerative diseases, have historically been transgenic and as suc...
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Authors
Contributors
+ Cunningham, T
Institution:
MRC Prion Unit at UCL
Division:
MSD
Department:
Clinical Neurosciences
Sub department:
Clinical Neurosciences
Oxford college:
Linacre College
Role:
Supervisor
+ Talbot, K
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Sub department:
Clinical Neurosciences
Research group:
Talbot
Oxford college:
Pembroke College
Role:
Supervisor
+ Vance, C
Institution:
Kings College London
Division:
MSD
Department:
Clinical Neurosciences
Sub department:
Clinical Neurosciences
Oxford college:
Pembroke College
Role:
Examiner
+ Cragg, S
Institution:
University of Oxford
Division:
MSD
Oxford college:
Christ Church
Role:
Examiner
Funding
+ Medical Research Council
More from this funder
Funder identifier:
https://ror.org/03x94j517
Funding agency for:
Price, G
Programme:
Oxford MRC-DTP
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-07-10
Terms of use
- Copyright holder:
- Georgia Price
- Copyright date:
- 2023
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