Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Bonilla, C; Lewis, S; Rowlands, M; Gaunt, T; Davey Smith, G; Gunnell, D; Palmer, T; Donovan, J; Hamdy, F; Neal, D; Eeles, R; Easton, D; Kote-Jarai, Z; Al Olama, A; Benlloch, S; Muir, K; Giles, G; Wiklund, F; Grönberg, H; Haiman, C; Schleutker, J; Nordestgaard, B; Travis, R; Pashayan, N; Khaw, K; Stanford, J; Blot, W; Thibodeau, S; Maier, C; Kibel, A; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, J; Kaneva, R; Batra, J; Teixeira, M; Pandha, H; Lathrop, M; Martin, R; Holly, J

Journal article

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Abstract:: Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate canc...
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Peer review status:: Peer reviewed

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APA Style

Bonilla, C., Lewis, S., Rowlands, M., Gaunt, T., Davey Smith, G., Gunnell, D., Palmer, T., Donovan, J., Hamdy, F., Neal, D., Eeles, R., Easton, D., Kote-Jarai, Z., Al Olama, A., Benlloch, S., Muir, K., Giles, G., Wiklund, F., Grönberg, H., … Holly, J. (2016). Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels. International Journal of Cancer, 139(7), 1520–1533.

MLA Style

Bonilla, C., et al. “Assessing the Role of Insulin-like Growth Factors and Binding Proteins in Prostate Cancer Using Mendelian Randomization: Genetic Variants as Instruments for Circulating Levels.” International Journal of Cancer, vol. 139, no. 7, Wiley, 2016, pp. 1520–33.

Chicago Style

Bonilla, C, S Lewis, M Rowlands, T Gaunt, G Davey Smith, D Gunnell, T Palmer, et al. 2016. “Assessing the Role of Insulin-like Growth Factors and Binding Proteins in Prostate Cancer Using Mendelian Randomization: Genetic Variants as Instruments for Circulating Levels.” International Journal of Cancer 139 (7): 1520–33.
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Publisher copy:: 10.1002/ijc.30206

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+ Bonilla, C More by this author

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Author

+ Lewis, S More by this author

Role:

Author

+ Rowlands, M More by this author

Role:

Author

+ Gaunt, T More by this author

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Author

+ Davey Smith, G More by this author

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Author

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Funding

+ Department of Defense More from this funder

Grant:

W81XWH-10–1-0341

+ Post-Cancer GWAS initiative More from this funder

Grant:

1U19CA148537,1U19CA148065

1U19CA148112-theGAME-ONinitiative

+ National Institutes of Health More from this funder

Grant:

CA128978

+ European Union More from this funder

Grant:

SeventhFrameworkProgramme(grantagreementn8223175);HEALTH-F2-2009–223175) (COGS)(toPRACTICAL

theiCOGSinfrastructure

+ Medical Research Council More from this funder

Grant:

G0600705, MC_UU_12013/19

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Bibliographic Details

Publisher:: Wiley
Journal:: International Journal of Cancer More from this journal
Volume:: 139
Issue:: 7
Pages:: 1520-1533
Publication date:: 2016-10-01
Acceptance date:: 2016-04-13
DOI:: 10.1002/ijc.30206
EISSN:: 1097-0215
ISSN:: 0020-7136
Pmid:: 27225428

Item Description

Language:: English
Keywords:: Mendelian randomization

UKHLS

prostate cancer

ALSPAC

single nucleotide polymorphisms

insulin-like growth factors

PRACTICAL consortium

PRACTICAL

ProtecT

insulin-like growth factor-binding proteins

IGFBP3
Pubs id:: pubs:615257
UUID:: uuid:ef626f83-f7ce-47b4-941c-72e219e861aa
Local pid:: pubs:615257
Source identifiers:: 615257
Deposit date:: 2016-09-12

Terms of use

Copyright holder:: Bonilla et al
Notes:: Copyright © 2016 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Licence:: CC Attribution (CC BY)

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Journal article

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

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