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Thesis

Investigating the role of IGF-1R in radio-sensitivity

Abstract:

The insulin-like growth factor (IGF) axis is an important regulator of cancer cell proliferation, growth, invasion, and can also mediate therapy resistance. Inhibition or depletion of the type 1 IGF receptor (IGF-1R) has been shown by our laboratory and others to enhance sensitivity to ionising radiation (IR) and chemotherapy, and to impair repair of DNA double-strand breaks (DSBs). Our group also reported association of high IGF1R expression with radio-resistance and biochemical recurrence a...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-8659-0192
Role:
Examiner
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Name:
Medical Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Funding agency for:
Ellis, M
Grant:
1943688
Programme:
Cell Signalling in Cancer
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
Deposit date:
2022-04-11

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