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First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131.

Abstract:
The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/AAC.00840-16

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Peirano, G More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
60
Issue:
8
Pages:
5068-5071
Publication date:
2016-05-31
Acceptance date:
2016-05-25
DOI:
ISSN:
0066-4804 and 1098-6596
Pubs id:
pubs:628120
URN:
uri:ef0c7956-7e1a-4083-a12b-c11736cadce8
UUID:
uuid:ef0c7956-7e1a-4083-a12b-c11736cadce8
Local pid:
pubs:628120
Language:
English
Keywords:

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