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High MDR‐1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR‐1 substrates

Abstract:

High expression of the ATP‐binding cassette‐multi‐drug efflux protein 1 (MDR1) is a striking feature of mucosal‐associated invariant T (MAIT) cells, a prominent human innate‐like T cell subset. We demonstrate significantly higher MDR1 expression by CD8 + CD161 ++ Vα7.2 + MAIT cells than the phenotypically and functionally related CD8 + CD161 ++ Vα7.2‐subset and show MDR1 expression to be similarly high throughout MAIT CD4 + , CD8 + , double‐negative (DN) and double‐positive (DP) cell subsets....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1111/cei.13165

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Author
Medical Research Council More from this funder
Biomedical Research Centre, Oxford More from this funder
Nuffield Department of Clinical Medicine, Oxford More from this funder
James Martin School for the 21st Century, Oxford More from this funder
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Publisher:
John Wiley and Sons, Ltd. Publisher's website
Journal:
Clinical and Experimental Immunology Journal website
Volume:
194
Issue:
2
Pages:
180-191
Publication date:
2018-09-19
Acceptance date:
2018-05-25
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
Pubs id:
pubs:920928
URN:
uri:ef03f633-c155-436a-89b8-035b2fe0acda
UUID:
uuid:ef03f633-c155-436a-89b8-035b2fe0acda
Local pid:
pubs:920928

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