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Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient

Abstract:

Background

Breast milk is the sole nutrition source during exclusive breastfeeding, and polyunsaturated fatty acids (FAs) are critical micronutrients in infant physical and cognitive development. There has been no prior genomewide association study of breast milk, hence our objective was to test for genetic association with breast milk FA composition.

Methods

We measured the fractional composition of 26 individual FAs in breast milk samples from three cohorts tota...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/jmedgenet-2017-105134

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Role:
Author
ORCID:
0000-0003-2595-0005
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Bill and Melinda Gates Foundation More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Medical Genetics Journal website
Volume:
55
Issue:
7
Pages:
459-468
Publication date:
2018-03-07
Acceptance date:
2018-02-08
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
Pubs id:
pubs:828461
URN:
uri:eee8d4db-3401-4ee4-9bf0-ab7264a304e9
UUID:
uuid:eee8d4db-3401-4ee4-9bf0-ab7264a304e9
Local pid:
pubs:828461

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