Journal article
Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation
- Abstract:
-
Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate decisions during placenta development remain ill defined. Here we exploited ATAC-seq and transcriptional profiling strategies to describe dynamic changes in gene expression and chromatin accessibility during TSC differentiation. We detect significantly increased chromatin accessibility at key genes upregulated as TSCs exit from the stem cel...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 7.4MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41598-017-06859-9
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 7
- Issue:
- 1
- Article number:
- 6793
- Publication date:
- 2017-07-28
- Acceptance date:
- 2017-06-19
- DOI:
- ISSN:
-
2045-2322
- Pmid:
-
28754907
Item Description
- Language:
-
English
- Pubs id:
-
pubs:710817
- UUID:
-
uuid:eee747f5-ce08-4562-a312-1b0ad6b6d84f
- Local pid:
-
pubs:710817
- Source identifiers:
-
710817
- Deposit date:
-
2017-11-15
Terms of use
- Copyright holder:
- Nelson et al
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record