Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.

Journal article

We previously identified autoantibodies to the endocytic-associated protein Huntingtin-interacting protein 1-related (HIP1R) in diffuse large B-cell lymphoma (DLBCL) patients. HIP1R regulates internalization of cell surface receptors via endocytosis, a process relevant to many therapeutic strategies including CD20 targeting with rituximab. In this study, we characterized HIP1R expression patterns, investigated a mechanism of transcriptional regulation and its clinical relevance in DLBCL patie...

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Authors: Wong, K; Gascoyne, D; Brown, P; Soilleux, E; Snell, C

• Publication status: Published
• Journal: Leukemia
• Volume: 28
• Issue: 2
• Pages: 362-372
• Publication date: 2014-02-01
• DOI: 10.1038/leu.2013.224
• EISSN: 1476-5551
• ISSN: 0887-6924
• Language: English
• Keywords: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Gene Expression Regulation, Neoplastic; Neoplasm Staging; Prednisone; Young Adult; Treatment Outcome; Adult; B-Lymphocytes; Aged; Female; Forkhead Transcription Factors; Vesicular Transport Proteins; Doxorubicin; Aged, 80 and over; Repressor Proteins; Lymphoma, Large B-Cell, Diffuse; Prognosis; Humans; Cyclophosphamide; Middle Aged; Vincristine; Protein Binding; Male