- Abstract:
-
The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from DNA in vitro. We demonstrate that PCF11-mediated termination is essential for vertebrate development. A range of genomic analyses, including mNET-seq, 3′ mRNA-seq, chromatin RNA-seq, and ChIP-seq, reveals that PCF11 enhances...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 3.9MB)
-
- Publisher copy:
- 10.1016/j.molcel.2019.01.027
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular Cell Journal website
- Volume:
- 74
- Issue:
- 4
- Pages:
- 158-172
- Publication date:
- 2019-02-25
- Acceptance date:
- 2019-01-17
- DOI:
- EISSN:
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1097-4164
- ISSN:
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1097-2765
- Pubs id:
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pubs:980259
- URN:
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uri:eebcb1ba-a9d4-4e32-b1ce-85c1cfec684f
- UUID:
-
uuid:eebcb1ba-a9d4-4e32-b1ce-85c1cfec684f
- Local pid:
- pubs:980259
- Copyright holder:
- Kamieniarz-Gdula et al.
- Copyright date:
- 2019
- Notes:
-
ª 2019 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Journal article
Selective roles of vertebrate PCF11 in premature and full-length transcript termination
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