HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition.

Journal article

Cancer-associated epithelial to mesenchymal transition (EMT) is crucial for invasion and metastasis. Molecular hallmarks of EMT include down-regulation of the epithelial adhesion protein E-cadherin and de-novo expression of N-cadherin and the mesenchymal intermediate filament proteins vimentin and fibronectin. Expression of HPV16 E7 in normal human epithelial cells caused increased levels of vimentin and fibronectin, whereas the epithelial adhesion protein E-cadherin was expressed at decrease...

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Authors: Hellner, K; Mar, J; Fang, F; Quackenbush, J; Münger, K

• Publication status: Published
• Journal: Virology
• Volume: 391
• Issue: 1
• Pages: 57-63
• Publication date: 2009-08-01
• DOI: 10.1016/j.virol.2009.05.036
• EISSN: 1096-0341
• ISSN: 0042-6822
• Language: English
• Keywords: Cell Transformation, Viral; Gene Expression; Cadherins; Epithelial Cells; Fibronectins; Genes, Viral; Human papillomavirus 16; Papillomavirus Infections; Cell Line; Cell Differentiation; Vimentin; Papillomavirus E7 Proteins; Humans; Repressor Proteins; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Viral; RNA, Messenger