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Hidden heritability due to heterogeneity across seven populations

Abstract:

The genome-wide association studies (GWAS) dominating genetic discovery are based on large meta-analyses that combine data from diverse historical time periods and populations. Polygenic scores constructed from GWAS explain only a fraction of the heritability derived from twin and whole-genome studies on single-populations, known as the ‘hidden heritability’ puzzle. Using seven sampling populations (N=35,062), we test whether hidden heritability is attributed to genetic heterogeneity, showing...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41562-017-0195-1

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Department:
Oxford, SSD, Sociology
Verweij, RM More by this author
van der Moost, PJ More by this author
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Funding agency for:
Mills, MC
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Funding agency for:
Mills, MC
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Funding agency for:
Mills, MC
Publisher:
Springer Nature Publisher's website
Journal:
Nature Human Behaviour Journal website
Volume:
1
Pages:
757–765
Publication date:
2017-09-11
Acceptance date:
2017-07-19
DOI:
ISSN:
2397-337
Pubs id:
pubs:708715
URN:
uri:ee8d72f1-aea3-4b81-afab-bcb2595a377e
UUID:
uuid:ee8d72f1-aea3-4b81-afab-bcb2595a377e
Local pid:
pubs:708715

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