Journal article
Rapid and efficient microwave-assisted Friedländer quinoline synthesis
- Abstract:
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A microwave‐based methodology facilitates reaction of 2‐aminophenylketones with cyclic ketones to form a quinoline scaffold. Syntheses of amido‐ and amino‐linked 17β‐hydroxysteroid dehydrogenase type 3 inhibitors with a benzophenone‐linked motif were pursued using 2‐aminobenzophenone as building block. Two amido‐linked targets were achieved in modest yield, but when using microwave‐assisted reductive amination for the amino‐linked counterparts an unexpected product was observed. X‐ray crystal...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.4MB, Terms of use)
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- Publisher copy:
- 10.1002/open.202000247
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Bibliographic Details
- Publisher:
- Wiley Open Access
- Journal:
- ChemistryOpen More from this journal
- Volume:
- 9
- Issue:
- 11
- Pages:
- 1113-1122
- Publication date:
- 2020-11-05
- Acceptance date:
- 2020-08-28
- DOI:
- EISSN:
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2191-1363
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1135619
- Local pid:
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pubs:1135619
- Deposit date:
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2020-09-30
Terms of use
- Copyright holder:
- Bailey et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 The Authors. Published by Wiley-VCH GmbH
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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