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Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation.

Abstract:

BACKGROUND: A 37-year-old woman presented with a supratentorial cerebral mass, which was diagnosed histologically as a primitive neuroectodermal tumor. She had been treated for rectal adenocarcinoma 7 years previously. A family history revealed a young-onset colorectal carcinoma in the patient's father. INVESTIGATIONS: Immunohistochemical analysis for DNA mismatch repair proteins, germline mutation analysis of MSH2. DIAGNOSIS: Lynch syndrome with a heterozygous germline mutation in MSH2. MAN...

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Publication status:
Published

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Publisher copy:
10.1038/nrclinonc.2009.35

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Frayling, I More by this author
Blesing, C More by this author
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Journal:
Nature reviews. Clinical oncology
Volume:
6
Issue:
5
Pages:
295-299
Publication date:
2009-05-05
DOI:
EISSN:
1759-4782
ISSN:
1759-4774
URN:
uuid:ee7ff270-054c-4fa2-8c76-e5311fccc22b
Source identifiers:
114317
Local pid:
pubs:114317

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