- Abstract:
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Background Genetic risk stratification may inform decisions of whether—and when—a man should undergo prostate cancer (PCa) screening. We previously validated a polygenic hazard score (PHS), a weighted sum of 54 single-nucleotide polymorphism genotypes, for accurate prediction of age of onset of aggressive PCa and improved screening performance. We now assess the potential impact of PHS-informed screening.Methods United Kingdom population data were fit to a continuous model of age-specific PCa...
Expand abstract - Publication status:
- Not Published
- Peer review status:
- Not peer reviewed
- Publisher copy:
- 10.1101/619718
-
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- Publisher:
- Cold Spring Harbor Laboratory Publisher's website
- Journal:
- bioRxiv Journal website
- Publication date:
- 2019-04-26
- DOI:
- Pubs id:
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pubs:996831
- URN:
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uri:ee7b510d-acd6-40d3-91f1-957543a8cf82
- UUID:
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uuid:ee7b510d-acd6-40d3-91f1-957543a8cf82
- Local pid:
- pubs:996831
- Keywords:
- Copyright holder:
- Huynh-Le et al.
- Copyright date:
- 2019
Journal article
A genetic hazard score to personalize prostate cancer screening, applied to population data
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