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Journal article

Needle-free dermal delivery of a diphtheria toxin CRM197 mutant on potassium-doped hydroxyapatite microparticles

Abstract:

Injections with a hypodermic needle and syringe (HNS) are the current standard of care globally, but the use of needles is not without limitation. While a plethora of needle-free injection devices exist, vaccine reformulation is costly and presents a barrier to their widespread clinical application. To provide a simple, needle-free, and broad-spectrum protein antigen delivery platform, we developed novel potassium-doped hydroxyapatite (K-Hap) microparticles with improved protein loading capab...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/cvi.00121-15

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
Oxford Martin School More from this funder
University of Oxford More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and vaccine immunology : CVI Journal website
Volume:
22
Issue:
5
Pages:
586-592
Publication date:
2015-01-01
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
Source identifiers:
517025
Language:
English
Pubs id:
pubs:517025
UUID:
uuid:ee7aa39e-7457-4217-ae1d-7d1ee7a6971e
Local pid:
pubs:517025
Deposit date:
2015-12-01

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