Journal article
Needle-free dermal delivery of a diphtheria toxin CRM197 mutant on potassium-doped hydroxyapatite microparticles
- Abstract:
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Injections with a hypodermic needle and syringe (HNS) are the current standard of care globally, but the use of needles is not without limitation. While a plethora of needle-free injection devices exist, vaccine reformulation is costly and presents a barrier to their widespread clinical application. To provide a simple, needle-free, and broad-spectrum protein antigen delivery platform, we developed novel potassium-doped hydroxyapatite (K-Hap) microparticles with improved protein loading capab...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, vnd.openxmlformats-officedocument, 890.7KB)
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- Publisher copy:
- 10.1128/cvi.00121-15
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Authors
Funding
Oxford Martin School
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University of Oxford
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Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Clinical and vaccine immunology : CVI Journal website
- Volume:
- 22
- Issue:
- 5
- Pages:
- 586-592
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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1556-679X
- ISSN:
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1556-6811
- Source identifiers:
-
517025
Item Description
- Language:
- English
- Pubs id:
-
pubs:517025
- UUID:
-
uuid:ee7aa39e-7457-4217-ae1d-7d1ee7a6971e
- Local pid:
- pubs:517025
- Deposit date:
- 2015-12-01
Terms of use
- Copyright holder:
- American Society for Microbiology
- Copyright date:
- 2015
- Notes:
- Copyright © 2015, American Society for Microbiology.
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