Ileal and faecal digestibility of daidzein and genistein and plasma bioavailability of these isoflavones and their bioactive metabolites in the ovariectomised rat.

Journal article

Consumption of the soya isoflavones genistein and daidzein may provide protection against postmenopausal bone loss. The purpose of this study was to determine ileal and faecal digestibility of daidzein and genistein and the extent of formation of metabolites in the gastrointestinal (GI) tract in the ovariectomised rat, a model for postmenopausal bone loss. Twenty female rats were ovariectomised and fed either genistein or daidzein (0.026% of diet) for 4 wks. Genistein, daidzein and their GI-d...

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Authors: Poulsen, R; Loots, D; Moughan, P; Kruger, M

• Publication status: Published
• Journal: Molecular nutrition and food research
• Volume: 53 Suppl 1
• Issue: SUPPL. 1
• Pages: S27-S35
• Publication date: 2009-05-01
• DOI: 10.1002/mnfr.200800080
• EISSN: 1613-4133
• ISSN: 1613-4125
• Language: English
• Keywords: Ileum; Feces; Osteoporosis, Postmenopausal; Phenols; Ovariectomy; Disease Models, Animal; Biological Availability; Equol; Isoflavones; Rats; Female; Animals; Rats, Sprague-Dawley; Genistein; Bacteria; Digestion; Humans