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Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial.

Abstract:

BACKGROUND: Evidence for efficacy of disease-modifying drugs in multiple sclerosis (MS) comes from trials of short duration. We report results from a 16 y, retrospective follow-up of the pivotal interferon beta-1b (IFNB-1b) study. METHODS: The 372 trial patients were randomly assigned to placebo (n=123), IFNB-1b 50 microg (n=125) or IFNB-1b 250 microg (n=124) subcutaneously every other day for at least 2 y. Some remained randomised for up to 5 y but, subsequently, patients received treatment ...

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Publication status:
Published

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Publisher copy:
10.1136/jnnp.2009.204123

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Traboulsee, A More by this author
Langdon, D More by this author
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Journal:
Journal of neurology, neurosurgery, and psychiatry
Volume:
81
Issue:
8
Pages:
907-912
Publication date:
2010-08-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:ee58537a-0581-4114-8830-fdaf8d065335
Source identifiers:
60719
Local pid:
pubs:60719

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