- Abstract:
-
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10(-8)), implicating gene...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 490.0KB)
-
(pdf, 1.0MB)
-
- Publisher copy:
- 10.1038/ncomms15539
-
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- Grant:
- 241,944, 339,462, 389,927, 389,875, 389,891, 389,892, 389,938, 443,036, 442,915, 442,981, 496,610, 496,739, 552,485, 552,498, 1,026,033 and 1,050,208
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 15539
- Publication date:
- 2017-05-24
- Acceptance date:
- 2017-04-07
- DOI:
- EISSN:
-
2041-1723
- ISSN:
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2041-1723
- Pubs id:
-
pubs:697781
- URN:
-
uri:ee51cefe-b4ae-4aa0-89e7-1e89f22d35f0
- UUID:
-
uuid:ee51cefe-b4ae-4aa0-89e7-1e89f22d35f0
- Local pid:
- pubs:697781
- Language:
- English
- Keywords:
- Copyright holder:
- Sapkota et al.
- Copyright date:
- 2017
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License.
Journal article
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
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+ National Health and Medical Research Council of Australia
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Cooperative Research Centre for Discovery of Genes for Common Human Diseases
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Cerylid Biosciences
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