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Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Abstract:

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10(-8)), implicating gene...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15539

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Morris, AP
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Funding agency for:
Rahmioglu, N
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Grant:
241,944, 339,462, 389,927, 389,875, 389,891, 389,892, 389,938, 443,036, 442,915, 442,981, 496,610, 496,739, 552,485, 552,498, 1,026,033 and 1,050,208
Cooperative Research Centre for Discovery of Genes for Common Human Diseases More from this funder
Cerylid Biosciences More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
15539
Publication date:
2017-05-24
Acceptance date:
2017-04-07
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:697781
URN:
uri:ee51cefe-b4ae-4aa0-89e7-1e89f22d35f0
UUID:
uuid:ee51cefe-b4ae-4aa0-89e7-1e89f22d35f0
Local pid:
pubs:697781
Language:
English
Keywords:

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