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Journal article

Single-cell transcriptomics of regulatory T Cells reveals trajectories of tissue adaptation

Abstract:

Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and spleen. In these tissues, we identified Treg cell subpopulations with distinct degrees of NLT phenotype. Subpopulation pseudotime ordering and gene kinetics were consistent in recruitment to skin and colon,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.immuni.2019.01.001

Authors


Publisher:
Elsevier Publisher's website
Journal:
Immunity Journal website
Volume:
50
Issue:
2
Pages:
493-504.e7
Publication date:
2019-02-05
Acceptance date:
2018-12-31
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Pmid:
30737144
Source identifiers:
975910
Language:
English
Keywords:
Pubs id:
pubs:975910
UUID:
uuid:ee45e009-85ad-4bf8-b537-a5779fe6c579
Local pid:
pubs:975910
Deposit date:
2019-03-13

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