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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

Abstract:
Background Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regulatory, non-coding RNAs, participate in senescence regulation. At the subcellular level micro-RNAs, similar to proteins, have been shown to traffic between organelles influencing cel... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s12864-017-4375-1

Authors


Komseli, E-S More by this author
Pateras, IS More by this author
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ORCID:
0000-0001-6350-1150
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ORCID:
0000-0002-6550-3384
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Publisher:
BMC Publisher's website
Journal:
BMC genomics Journal website
Volume:
37
Issue:
19
Publication date:
2018-01-10
Acceptance date:
2017-12-11
DOI:
EISSN:
1471-2164
Pubs id:
pubs:820981
URN:
uri:ee23e250-d34a-4f4a-9431-7a5ea42d28eb
UUID:
uuid:ee23e250-d34a-4f4a-9431-7a5ea42d28eb
Local pid:
pubs:820981

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