Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

Journal article

To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This 220-kb region includes the alpha globin genes and 9 widely expressed genes flanking the alpha globin locus. This un-biased, comprehensive analysis of transcription factor binding...

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Authors: De Gobbi, M; Anguita, E; Hughes, J; Sloane-Stanley, J; Sharpe, J

• Publication status: Published
• Journal: Blood
• Volume: 110
• Issue: 13
• Pages: 4503-4510
• Publication date: 2007-12-01
• DOI: 10.1182/blood-2007-06-097964
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Enhancer Elements, Genetic; Cells, Cultured; Humans; Transcription, Genetic; Mice; Globins; Acetylation; Animals; Telomere; Histones; K562 Cells; Erythroblasts; Methylation; Transcription Factors; Chromosomes, Human, Pair 16; Gene Expression Regulation; Promoter Regions, Genetic; T-Lymphocytes