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Journal article

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

Abstract:

To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This 220-kb region includes the alpha globin genes and 9 widely expressed genes flanking the alpha globin locus. This un-biased, comprehensive analysis of transcription factor binding...

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Publication status:
Published

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Authors


De Gobbi, M More by this author
Anguita, E More by this author
Sloane-Stanley, JA More by this author
Sharpe, JA More by this author
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Journal:
Blood
Volume:
110
Issue:
13
Pages:
4503-4510
Publication date:
2007-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:edc2afb9-dbba-426e-a18b-679af27ab84c
Source identifiers:
56251
Local pid:
pubs:56251

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