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Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn’s disease

Abstract:

For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis)1,2,3. Prognosis may vary substantially between patients for reasons that are poorly understood. Familial studies support a genetic contribution to prognosis4,5,6, but little evidence has been found for a proposed association between prognosis and the burden of susceptibility variants7,8,9,10,11,12,13. To better characteri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.3755

Authors


Roberts, R More by this author
Gearry, RB More by this author
Mansfield, JC More by this author
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Funding agency for:
Lee, JC
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Funding agency for:
Biasci, D
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Funding agency for:
Prescott, NJ
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Funding agency for:
Anderson, CA
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Funding agency for:
Traherne, JA
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
262-268
Publication date:
2017-01-09
Acceptance date:
2016-11-29
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:896961
URN:
uri:eda48192-85e1-48d0-95bb-7814e9310ea3
UUID:
uuid:eda48192-85e1-48d0-95bb-7814e9310ea3
Local pid:
pubs:896961

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