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The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.

Abstract:

DNA polymerase delta (Pol delta) plays a central role in eukaryotic chromosomal DNA replication, repair and recombination. In fission yeast, Pol delta is a tetrameric enzyme, comprising the catalytic subunit Pol3 and three smaller subunits, Cdc1, Cdc27 and Cdm1. Previous studies have demonstrated a direct interaction between Pol3 and Cdc1, the B-subunit of the complex. Here it is shown that removal of the tandem zinc finger modules located at the C-terminus of Pol3 by targeted proteolysis ren...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkh623

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Nucleic acids research
Volume:
32
Issue:
10
Pages:
3005-3016
Publication date:
2004-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:ed9eaed7-38fe-47e8-87d9-3e88ded0f366
Source identifiers:
209692
Local pid:
pubs:209692

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